Neuroscience, Chemical biology
Our group studies the molecular and cell biological mechanisms of learning-related neuronal plasticity, a process in which the strength and the number of synaptic connections in our brain are altered by experience. Such structural and functional changes occur in an activity-dependent manner and are mediated by highly orchestrated gene networks. Our goal is to gain fundamental understanding of the regulation of gene expression within the neural circuits during long-term neuronal plasticity, with an emphasis on the spatiotemporal regulation mechanisms. In an essential effort to achieve this goal, we are developing effective RNA live-imaging methods for sensitive and quantitative imaging of RNA dynamics in living neural circuits. Our research has a strong orientation to incorporate novel bioactive materials and chemical approaches to study gene regulation and neuron function, which drives us to do cross-disciplinary collaboration research inside and outside our institute.